期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 43, 页码 17522-17527出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1308632110
关键词
enteric disease; drug resistance; phylogeography; genomics
资金
- Wellcome Trust [098051]
- Wellcome Trust
- Vietnamese Initiative for Zoonotic Infections hospital disease surveillance consortium
- Li Ka Shing Foundation of China
- Royal Society Sir Henry Dale Fellowship
- National Health and Medical Research Council (Australia) [628930]
- Basic Science Research Program through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [2012R1A2A2A01009741]
- National Research Foundation of Korea [2012R1A2A2A01009741] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.
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