期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 48, 页码 19414-19419出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1309720110
关键词
migration; invasion; protein trafficking
资金
- National Institutes of Health [R01 CA137071]
- National Science Foundation Graduate Research Fellowship [DGE-0809128]
- Austrian Science Research Fund [P23729-B11]
- Austrian Science Fund (FWF) [P 23729, I 1207, I 413] Funding Source: researchfish
- Austrian Science Fund (FWF) [P23729] Funding Source: Austrian Science Fund (FWF)
We recently demonstrated that plectin is a robust biomarker for pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive malignancies. In normal physiology, plectin is an intracellular scaffolding protein, but we have demonstrated localization on the extracellular surface of PDAC cells. In this study, we confirmed cell surface localization. Interestingly, we found that plectin cell surface localization was attributable to its presence in exosomes secreted from PDAC cells, which is dependent on the expression of integrin beta 4, a protein known to interact with cytosolic plectin. Moreover, plectin expression was necessary for efficient exosome production and was required to sustain enhanced tumor growth in immunodeficient and in immunocompetent mice. It is now clear that this PDAC biomarker plays a role in PDAC, and further understanding of plectin's contribution to PDAC could enable improved therapies.
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