期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 18, 页码 7464-7469出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1304422110
关键词
long-term memory storage; RNA transport; local protein synthesis; neurogenomics; cystoskeleton
资金
- Howard Hughes Medical Institute
- National Institutes of Health [P50 HG002806, MH075026, 1R01 NS060762, 1R01 GM097502, R21RR025699, 5R21DA030118]
- McKnight Brain Research Foundation
- Whitehall Foundation
- National Science Foundation [0744649]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1146575] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0744649] Funding Source: National Science Foundation
Here we describe a strategy designed to identify RNAs that are actively transported to synapses during learning. Our approach is based on the characterization of RNA transport complexes carried by molecular motor kinesin. Using this strategy in Aplysia, we have identified 5,657 unique sequences consisting of both coding and noncoding RNAs from the CNS. Several of these RNAs have key roles in the maintenance of synaptic function and growth. One of these RNAs, myosin heavy chain, is critical in presynaptic sensory neurons for the establishment of long-term facilitation, but not for its persistence.
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