期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 12, 页码 4810-4815出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1301996110
关键词
inflammasome; inflammation; lipoprotein
资金
- National Institutes of Health [AI R01 046688, AI R01 055502, DK R01 40936, U24 DK 059635]
- MSTP [TG 2T32GM07205]
- Yale Diabetes Endocrine Research Center [2 P30 DK 045735]
Caspase-1 is a cysteine protease that can be activated by both endogenous and exogenous inflammatory stimuli and has been shown to have important functions in processes as diverse as proteolytic activation of cytokines, cell death, and membrane repair. Caspase-1-dependent production of the inflammatory cytokines IL-1 and IL-18 has also been implicated in the regulation of appetite, body weight, glucose homeostasis, and lipid metabolism. Consistent with the emerging views of caspase-1 in metabolic regulation, we find that caspase-1-deficient mice have dramatically accelerated triglyceride clearance, without alteration in lipid production or absorption, and resultant decrease in steady-state circulating triglyceride and fatty acid levels. Surprisingly, this effect is independent of IL-1-family signaling, supporting the concept that caspase-1 influences lipid metabolism through multiple mechanisms, not limited to cytokines.
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