期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 28, 页码 11105-11109出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1209288109
关键词
C. elegans manipulation; cell manipulation; microfluidics; lab on a chip
资金
- National Institutes of Health [1DP2OD007209-01]
- National Science Foundation (NSF) [1102206, DGE-0750756]
- Penn State Center for Nanoscale Science (MRSEC)
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1102206] Funding Source: National Science Foundation
Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based acoustic tweezers that can trap and manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans) in a single-layer microfluidic chip. Our acoustic tweezers utilize the wide resonance band of chirped interdigital transducers to achieve real-time control of a standing surface acoustic wave field, which enables flexible manipulation of most known microparticles. The power density required by our acoustic device is significantly lower than its optical counterparts (10,000,000 times less than optical tweezers and 100 times less than optoelectronic tweezers), which renders the technique more biocompatible and amenable to miniaturization. Cell-viability tests were conducted to verify the tweezers' compatibility with biological objects. With its advantages in biocompatibility, miniaturization, and versatility, the acoustic tweezers presented here will become a powerful tool for many disciplines of science and engineering.
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