期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 36, 页码 14693-14698出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1212547109
关键词
A-type protein phosphatase 2C; signal transduction; small GTPase
资金
- National Science Foundation of China [NSFC-31170229, NSFC-30970273]
- National High Technology Research and Development Program of China [2010AA101305]
- National Science Foundation
- Fundacao para a Ciencia e Tecnologia (Portugal)
- University of Massachusetts Plant Biology Graduate Program Gilgut Fellowship
- Key Program for Science and Technology of Hunan Province [2009FJ1004-1, 2009FJ1004-2]
Plant growth and development are controlled by a delicate balance of hormonal cues. Growth-promoting hormones and growth-inhibiting counterparts often antagonize each other in their action, but the molecular mechanisms underlying these events remain largely unknown. Here, we report a cross-talk mechanism that enables a receptor-like kinase, FERONIA (FER), a positive regulator of auxin-promoted growth, to suppress the abscisic acid (ABA) response through activation of ABI2, a negative regulator of ABA signaling. The FER pathway consists of a FER kinase interacting with guanine exchange factors GEF1, GEF4, and GEF10 that, in turn, activate GTPase ROP11/ARAC10. Arabidopsis mutants disrupted in any step of the FER pathway, including fer, gef1gef4gef10, or rop11/arac10, all displayed an ABA-hypersensitive response, implicating the FER pathway in the suppression mechanism. In search of the target for the FER pathway, we found that the ROP11/ARAC10 protein physically interacted with the ABI2 phosphatase and enhanced its activity, thereby linking the FER pathway with the inhibition of ABA signaling.
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