期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 8, 页码 3131-3136出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1121329109
关键词
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资金
- NIH [1U54MH091657-01, R01 EB000331, P30 NS057091, P41 RR08079]
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/C519938/1] Funding Source: researchfish
- Medical Research Council [G0700399] Funding Source: researchfish
- MRC [G0700399] Funding Source: UKRI
Resting-state functional magnetic resonance imaging has become a powerful tool for the study of functional networks in the brain. Even at rest, the brain's different functional networks spontaneously fluctuate in their activity level; each network's spatial extent can therefore be mapped by finding temporal correlations between its different subregions. Current correlation-based approaches measure the average functional connectivity between regions, but this average is less meaningful for regions that are part of multiple networks; one ideally wants a network model that explicitly allows overlap, for example, allowing a region's activity pattern to reflect one network's activity some of the time, and another network's activity at other times. However, even those approaches that do allow overlap have often maximized mutual spatial independence, which may be suboptimal if distinct networks have significant overlap. In this work, we identify functionally distinct networks by virtue of their temporal independence, taking advantage of the additional temporal richness available via improvements in functional magnetic resonance imaging sampling rate. We identify multiple temporal functional modes, including several that subdivide the default-mode network (and the regions anticorrelated with it) into several functionally distinct, spatially overlapping, networks, each with its own pattern of correlations and anticorrelations. These functionally distinct modes of spontaneous brain activity are, in general, quite different from resting-state networks previously reported, and may have greater biological interpretability.
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