期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 12, 页码 4574-4579出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1118892109
关键词
expansion time; admixture time; migration rate; single nucleotide polymorphism
资金
- Ministry of Science and Technology International Cooperation Base of China
- National Science Foundation of China [31171218, 30971577, 30890034]
- Shanghai Rising-Star Program [11QA1407600]
- Science Foundation of the Chinese Academy of Sciences (CAS) [KSCX2-EW-Q-1-11, KSCX2-EW-R-01-05, KSCX2-EW-J-15-05]
- K. C. Wong Education Foundation, Hong Kong
- Max Planck Society
- German Research Council [Sonderforschungsbereich 680]
- Grants-in-Aid for Scientific Research [22133002, 23247040] Funding Source: KAKEN
Although the Austronesian expansion had a major impact on the languages of Island Southeast Asia, controversy still exists over the genetic impact of this expansion. The coexistence of both Asian and Papuan genetic ancestry in Eastern Indonesia provides a unique opportunity to address this issue. Here, we estimate recombination breakpoints in admixed genomes based on genome-wide SNP data and date the genetic admixture between populations of Asian vs. Papuan ancestry in Eastern Indonesia. Analyses of two genome-wide datasets indicate an eastward progression of the Asian admixture signal in Eastern Indonesia beginning about 4,000-3,000 y ago, which is in excellent agreement with inferences based on Austronesian languages. The average rate of spread of Asian genes in Eastern Indonesia was about 0.9 km/y. Our results indicate that the Austronesian expansion had a strong genetic as well as linguistic impact on Island Southeast Asia, and they significantly advance our understanding of the biological origins of human populations in the Asia-Pacific region.
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