期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 44, 页码 17931-17935出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1215241109
关键词
transcriptional initiation; X-ray crystallography; cross-linking; yeast
资金
- National Institutes of Health (NIH) [GM49985, GM36659, AI21144, P41GM103393, P41RR001209]
- NIH National Institute of General Medical Sciences [8P41GM103481]
- Howard Hughes Medical Institute
- Department of Energy
- National Cancer Institute [Y1-CO-1020]
- National Institute of General Medical Sciences [Y1-GM-1104]
The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.
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