期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 50, 页码 20697-20702出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1218246109
关键词
sexual dimorphism; neural circuit; fruitless
资金
- Gosney fellowship (Caltech Biology)
- National Institutes of Health [NS007251]
- National Research Service Award Fellowship [5F32NS058132]
- HHMI Predoctoral Fellowship
- National Science Foundation Frontiers in Integrative Biological Research Grant [EF-0623527]
- Alfred P. Sloan Foundation
- Human Frontiers Science Program
- Klingenstein Fund
- McKnight Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1054578] Funding Source: National Science Foundation
Innate behaviors are often executed in concert with accompanying physiological programs. How this coordination is achieved is poorly understood. Mating behavior and the transfer of sperm and seminal fluid (SSFT) provide a model for understanding how concerted behavioral and physiological programs are coordinated. Here we identify a male-specific neural pathway that coordinates the timing of SSFT with the duration of copulation behavior in Drosophila. Silencing four abdominal ganglion (AG) interneurons (INs) that contain the neuropeptide corazonin (Crz) both blocked SSFT and substantially lengthened copulation duration. Activating these Crz INs caused rapid ejaculation in isolated males, a phenotype mimicked by injection of Crz peptide. Crz promotes SSFT by activating serotonergic (5-HT) projection neurons (PNs) that innervate the accessory glands. Activation of these PNs in copulo caused premature SSFT and also shortened copulation duration. However, mating terminated normally when these PNs were silenced, indicating that SSFT is not required for appropriate copulation duration. Thus, the lengthened copulation duration phenotype caused by silencing Crz INs is independent of the block to SSFT. We conclude that four Crz INs independently control SSFT and copulation duration, thereby coupling the timing of these two processes.
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