期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 45, 页码 18290-18294出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1204460109
关键词
radiation dose reduction; iterative algorithm; analyzer based imaging
资金
- UC Discovery/TomoSoft Technologies [IT107-10166]
- National Institutes of Health [GM081409-01A1]
- DFG-Cluster of Excellence Munich-Centre for Advanced Photonics [EXE158]
Mammography is the primary imaging tool for screening and diagnosis of human breast cancers, but similar to 10-20% of palpable tumors are not detectable on mammograms and only about 40% of biopsied lesions are malignant. Here we report a high-resolution, low-dose phase contrast X-ray tomographic method for 3D diagnosis of human breast cancers. By combining phase contrast X-ray imaging with an image reconstruction method known as equally sloped tomography, we imaged a human breast in three dimensions and identified a malignant cancer with a pixel size of 92 mu m and a radiation dose less than that of dual-view mammography. According to a blind evaluation by five independent radiologists, our method can reduce the radiation dose and acquisition time by similar to 74% relative to conventional phase contrast X-ray tomography, while maintaining high image resolution and image contrast. These results demonstrate that high-resolution 3D diagnostic imaging of human breast cancers can, in principle, be performed at clinical compatible doses.
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