期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 52, 页码 21289-21294出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1216441109
关键词
biomimicry; medical tape; microneedle; sutures; staples
资金
- National Institutes of Health (NIH) [GM086433]
- American Heart Association [0835601D]
- National Science Foundation [NIRT 0609182]
- NIH [DE013023]
- National Research Foundation of Korea [NRF-2010-357-D00277]
- Korean Government (Ministry of Education, Science and Technology)
- National Science Foundation
- Hugh Hampton Young Memorial Fund
- Massachusetts Institute of Technology Undergraduate Research Opportunities Program
- China Scholarship Council
- National Natural Science Foundation of China [51273159, 51072159]
- Program for New Century Excellent Talents in Universities (Chinese Ministry of Education) [2301G107aaa, NCET-08-0444]
North American porcupines are well known for their specialized hairs, or quills that feature microscopic backward-facing deployable barbs that are used in self-defense. Herein we show that the natural quill's geometry enables easy penetration and high tissue adhesion where the barbs specifically contribute to adhesion and unexpectedly, dramatically reduce the force required to penetrate tissue. Reduced penetration force is achieved by topography that appears to create stress concentrations along regions of the quill where the cross sectional diameter grows rapidly, facilitating cutting of the tissue. Barbs located near the first geometrical transition zone exhibit the most substantial impact on minimizing the force required for penetration. Barbs at the tip of the quill independently exhibit the greatest impact on tissue adhesion force and the cooperation between barbs in the 0-2 mm and 2-4 mm regions appears critical to enhance tissue adhesion force. The dual functions of barbs were reproduced with replica molded synthetic polyurethane quills. These findings should serve as the basis for the development of bio-inspired devices such as tissue adhesives or needles, trocars, and vascular tunnelers where minimizing the penetration force is important to prevent collateral damage.
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