期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 34, 页码 E2258-E2266出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1116738109
关键词
neural stem cell; segmentation; Hox
资金
- Volkswagen Foundation Conditional Activation of Gene Expression
- Deutsche Forschungsgemeinschaft (DFG) [DFG-SFB655, SPP1109 DFG TA-275/1-3, DFG TA-274/3-1]
- Max Planck Institute of Molecular Cell Biology and Geneticsand from the DFG Center for Regenerative Therapies Dresden
We show that after tail amputation in Ambystoma mexicanum (Axolotl) the correct number and spacing of dorsal root ganglia are regenerated. By transplantation of spinal cord tissue and non-clonal neurospheres, we show that the central spinal cord represents a source of peripheral nervous system cells. Interestingly, melanophores migrate from preexisting precursors in the skin. Finally, we demonstrate that implantation of a clonally derived spinal cord neurosphere can result in reconstitution of all examined cell types in the regenerating central spinal cord, suggesting derivation of a cell with spinal cord stem cell properties.
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