期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 19, 页码 7196-7201出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1202762109
关键词
desulfurization; solid phase peptide synthesis
资金
- National Institutes of Health [CA28824]
- Sloan-Kettering Institute
- [T32 CA062948-15]
Nonglycosylated erythropoietin bearing acetamidomethyl protecting groups at the cysteine residues has been synthesized via chemical methods. Alanine ligation was used to assemble four peptide fragments, themselves prepared by solid phase peptide synthesis. This work outlines a route for the synthesis of homogeneous glycosylated erythropoietin.
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