期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 26, 页码 10199-10204出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1117861109
关键词
X-ray dark-field imaging; X-ray medical imaging; X-ray phase-contrast imaging; X-ray microtomography; paleontology
资金
- Cluster of Excellence Munich-Center for Advanced Photonics of Deutsche Forschungsgemeinschaft [DFG EXC-158]
- European Research Council [24012]
- French research networks (reseaux thematiques de recherche avancee, RTRA) Digiteo and Triangle de la Physique [2009-034T, 2009-79D]
- Karlsruhe Nano Micro Facility (KNMF)
X-ray grating interferometry is a coherent imaging technique that bears tremendous potential for three-dimensional tomographic imaging of soft biological tissue and other specimens whose details exhibit very weak absorption contrast. It is intrinsically trimodal, delivering phase contrast, absorption contrast, and scattering (dark-field) contrast. Recently reported acquisition strategies for grating-interferometric phase tomography constitute a major improvement of dose efficiency and speed. In particular, some of these techniques eliminate the need for scanning of one of the gratings (phase stepping). This advantage, however, comes at the cost of other limitations. These can be a loss in spatial resolution, or the inability to fully separate the three imaging modalities. In the present paper we report a data acquisition and processing method that optimizes dose efficiency but does not share the main limitations of other recently reported methods. Although our method still relies on phase stepping, it effectively uses only down to a single detector frame per projection angle and yields images corresponding to all three contrast modalities. In particular, this means that dark-field imaging remains accessible. The method is also compliant with data acquisition over an angular range of only 180 degrees and with a continuous rotation of the specimen.
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