期刊
EPIGENOMICS
卷 7, 期 8, 页码 1245-1258出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.85
关键词
cancer; DNA methylation; endocrine tumors; growth factors; insulinomas; pancreatic endocrine tumors; tumor classification
资金
- EU (MolPAGE) [LSHG-CT-2004-512066]
- French Ministry of Research
Aim: Most studies have considered gastroenteropancreatic neuroendocrine tumors (GEP-NETs) as a homogenous group of samples or distinguish only gastrointestinal from pancreatic endocrine tumors. This article investigates if DNA methylation patterns could distinguish subtypes of GEP-NETs. Materials & methods: The DNA methylation level of 807 cancer-related genes was investigated in insulinomas, gastrinomas, non-functioning pancreatic endocrine tumors (NF-PETs) and small intestine endocrine tumors (SIETs). Results: DNA methylation patterns were found to be tumor type specific for each of the pancreatic tumor subtypes and identified two distinct methylation-based groups in SIETs. Differences of DNA methylation levels were validated by pyrosequencing for 20 candidate genes and correlated with differences at the transcriptional level for four candidate genes. Conclusion: The heterogeneity of DNA methylation patterns in the different subtypes of GEP-NETs suggests different underlying pathways and, therefore, these tumors should be considered as distinct entities in molecular and clinical studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据