期刊
EPIGENOMICS
卷 7, 期 6, 页码 975-984出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.37
关键词
cancer biomarker; cancer therapy; epigenetic network; piRNA; PIWI
资金
- NCI NIH HHS [P30 CA006973] Funding Source: Medline
Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.
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