期刊
EPIGENOMICS
卷 7, 期 3, 页码 379-393出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.2
关键词
blood lead levels; differential methylation; DNA methylation; dried blood spots; epigenetics; gene specific; lead; whole blood
资金
- WSU-NIEHS Center [P30 ES020957]
- Institute for Population Sciences, Health Assessment, Administration, Services and Economics (INPHAASE) from Wayne State University
- Henry Ford Medical Center
- National Health and Nutrition Examination Survey)
- BLEEP (The Michigan Bloodspot Environmental Epidemiology Project) pilot grant from the University Research Corridor (URC)
- NSF [DUE-9952410]
- [R01 ES012933]
- [R21 ES021893]
Aims: In this paper, we tested the hypothesis that early life lead (Pb) exposure associated DNA methylation (5 mC) changes are dependent on the sex of the child and can serve as biomarkers for Pb exposure. Methods: In this pilot study, we measured the 5mC profiles of DNA extracted from dried blood spots (DBS) in a cohort of 43 children (25 males and 18 females; ages from 3 months to 5 years) from Detroit. Result & Discussion: We found that the effect of Pb-exposure on the 5-mC profiles can be separated into three subtypes: affected methylation loci which are conserved irrespective of the sex of the child (conserved); affected methylation loci unique to males (male-specific); and affected methylation loci unique to females (female-specific).
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