期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 37, 页码 15456-15461出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1106862108
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资金
- Indiana University
- National Institutes of Health [NS052524]
The proper distribution of mitochondria is particularly vital for neurons because of their polarized structure and high energy demand. Mitochondria in axons constantly move in response to physiological needs, but signals that regulate mitochondrial movement are not well understood. Aside from producing ATP, Ca2+ buffering is another main function of mitochondria. Activities of many enzymes in mitochondria are also Ca2+-dependent, suggesting that intramitochondrial Ca2+ concentration is important for mitochondrial functions. Here, we report that mitochondrial motility in axons is actively regulated by mitochondrial matrix Ca2+. Ca2+ entry through the mitochondrial Ca2+ uniporter modulates mitochondrial transport, and mitochondrial Ca2+ content correlates inversely with the speed of mitochondrial movement. Furthermore, the miro1 protein plays a role in Ca2+ uptake into the mitochondria, which subsequently affects mitochondrial movement.
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