期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 20, 页码 8473-8478出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1100428108
关键词
blood oxygen level-dependent functional MRI; neurovascular coupling; two-photon imaging; vasomotion; vibrissa somatosensation
资金
- National Institutes of Health [EB003832, MH085499, NS059832, OD006831]
- American Heart Association
Neural activity in the brain is followed by localized changes in blood flow and volume. We address the relative change in volume for arteriole vs. venous blood within primary vibrissa cortex of awake, head-fixed mice. Two-photon laser-scanning microscopywas used to measure spontaneous and sensory evoked changes in flow and volume at the level of single vessels. We find that arterioles exhibit slow (<1 Hz) spontaneous increases in their diameter, as well as pronounced dilation in response to both punctate and prolonged stimulation of the contralateral vibrissae. In contrast, venules dilate only in response to prolonged stimulation. We conclude that stimulation that occurs on the time scale of natural stimuli leads to a net increase in the reservoir of arteriole blood. Thus, a bagpipe model that highlights arteriole dilation should augment the current balloon model of venous distension in the interpretation of fMRI images.
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