期刊
EPIGENOMICS
卷 7, 期 8, 页码 1275-1285出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.68
关键词
BAGE; childhood trauma; DNA methylation; first-episode schizophrenia; LINE-1; repetitive DNA sequences; stress
资金
- National Science Centre [DEC-2011/03/N/NZ5/00248]
- START scholarship by Foundation for Polish Science
Aim: We investigated methylation of DNA repetitive sequences (LINE-1 and BAGE) in peripheral blood leukocytes from first-episode schizophrenia (FES) patients and healthy controls (HCs) with respect to childhood adversities. Materials & methods: Patients were divided into two subgroups based on the history of childhood trauma -FES(+) and FES(-) subjects. The majority of HCs had a negative history of childhood trauma -HCs(-) subjects. Results: FES(+) patients had significantly lower LINE-1 methylation in comparison with FES(-) patients or HC(-) subjects. Emotional abuse and total trauma score predicted lower LINE-1 methylation in FES patients, while general trauma score was associated with lower BAGE methylation in HCs. Conclusion: Childhood adversities might be associated with global DNA hypomethylation in adult FES patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据