期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 44, 页码 18044-18048出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1113395108
关键词
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资金
- German Research Foundation [WA-2590/1-1]
- Fondation Recherche Medicale
- Charles A. Dana Foundation
Long-term humoral immunity is maintained by the formation of high-affinity class-switched memory B cells and long-lived anti-body-secreting plasma cells. In healthy humans, a substantial fraction of IgG-positive memory B cells express self-reactive and polyreactive IgG antibodies that frequently develop by somatic mutations. Whether self-and polyreactive IgG-secreting B cells are also tolerated in the long-lived plasma cell pool is not known. To address this question, we cloned and expressed the Ig genes from 177 IgG-producing bone marrow plasma cells of four healthy donors. All antibodies were highly mutated but the frequency of self-and polyreactive IgG antibodies was significantly lower than that found in circulating memory B cells. The data suggest that in contrast to the development of memory B cells, entry into the bone marrow plasma cell compartment requires previously unappreciated selective regulation by mechanisms that limit the production of self-and polyreactive serum IgG antibodies.
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