4.8 Article

Reconciliation of opposing views on membrane-sugar interactions

出版社

NATL ACAD SCIENCES
DOI: 10.1073/pnas.1012516108

关键词

membrane interface; membrane structure; preferential binding; preferential exclusion; interaction free energy

资金

  1. Lundbeck Foundation
  2. Danish Agency for Science, Technology and Innovation [272-06-0505]
  3. Danish National Research Foundation through the establishment of the MEMPHYS Center of Excellence
  4. Danscatt user program

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It is well established that small sugars exert different types of stabilization of biomembranes both in vivo and in vitro. However, the essential question of whether sugars are bound to or expelled from membrane surfaces, i.e., the sign and size of the free energy of the interaction, remains unresolved, and this prevents a molecular understanding of the stabilizing mechanism. We have used small-angle neutron scattering and thermodynamic measurements to show that sugars may be either bound or expelled depending on the concentration of sugar. At low concentration, small sugars bind quite strongly to a lipid bilayer, and the accumulation of sugar at the interface makes the membrane thinner and laterally expanded. Above similar to 0.2 M the sugars gradually become expelled from the membrane surface, and this repulsive mode of interaction counteracts membrane thinning. The dual nature of sugar-membrane interactions offers a reconciliation of conflicting views in earlier reports on sugar-induced modulations of membrane properties.

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