期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 41, 页码 17201-17206出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1114241108
关键词
gamma oscillations; synaptic transmission; Cre recombinase; dendrite; slice
资金
- National Institute of Mental Health
- Swedish Research Council
- National Institutes of Health/Karolinska Institutet
- National Institutes of Health [NS050596]
Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV-/-) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amplitude of glutamatergic inputs to PV+ interneurons and the frequency of GABAergic inputs to excitatory pyramidal cells were reduced in the TrkB-PV-/- mice. Functionally, rhythmic network activity in the gamma-frequency band (30-80 Hz) was significantly decreased in hippocampal area CA1. This decrease was caused by a desynchronization and overall reduction in frequency of action potentials generated in PV+ interneurons of TrkB-PV-/- mice. Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV-/- mice, resulting in decreased rhythmic network activity in the gamma-frequency band.
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