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A new genetic lesion in B-CLL: a NOTCH1 PEST domain mutation
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Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment
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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Raphael Kopan et al.
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HPV & head and neck cancer: a descriptive update
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A nonclassical bHLH-Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling
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Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
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Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
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Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
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Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases
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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Andrew P. Weng et al.
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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
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Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
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Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA
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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
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CELL (2006)
PIK3CA mutations in head and neck squamous cell carcinoma
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New roles for integrins in squamous-cell carcinoma
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Mutations in NOTCH1 cause aortic valve disease
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Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of fringe
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P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
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Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck
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Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)
Structural and functional properties of the human Notch-1 ligand binding region
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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
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Notch1 functions as a tumor suppressor in mouse skin
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Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
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dbSNP: the NCBI database of genetic variation
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NUCLEIC ACIDS RESEARCH (2001)