期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 18, 页码 7505-7510出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1016048108
关键词
natural killer cells; viral evolution; neutralizing antibody
资金
- National Health and Medical Research Council [510448]
- Australian Research Council [LP0991498]
- National Institutes of Health [R21AI081541]
- Australian Centre for HIV and Hepatitis Virology Research
- Royal Australasian College of Physicians
- Ramaciotti Foundation
- Australian Research Council [LP0991498] Funding Source: Australian Research Council
Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using a flow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitope derived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies were unable to recognize the concurrent HIV sequence. Our studies suggest ADCC responses apply significant immune pressure on the virus. This result has implications for the induction of ADCC responses by HIV vaccines.
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