期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 7, 页码 3080-3085出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1014218108
关键词
social genomics; inflammation; bioinformatics; ecological immunology
资金
- National Institutes of Health [P01 AG19811, P20 RR020645, P30 AG028748, R01 AI52737, R01 CA116778, R01 AG033590]
- Mind, Body, Brain, and Health Initiative of the John D. and Catherine T. MacArthur Foundation
- Norman Cousins Center at UCLA
- John Templeton Foundation
- James B. Pendleton Charitable Trust
To clarify the biological rationale for social regulation of gene expression, this study sought to identify the specific immune cell types that are transcriptionally sensitive to subjective social isolation (loneliness). Using reference distributions for the expression of each human gene in each major leukocyte subtype, we mapped the cellular origin of transcripts found to be differentially expressed in the circulating immune cells from chronically lonely individuals. Loneliness-associated genes derived primarily from plasmacytoid dendritic cells, monocytes, and, to a lesser extent, B lymphocytes. Those dynamics reflected per-cell changes in the expression of inducible genes and related more strongly to the subjective experience of loneliness than to objective social network size. Evolutionarily ancient myeloid antigen-presenting cells appear to have evolved a transcriptional sensitivity to socioenvironmental conditions that may allow them to shift basal gene expression profiles to counter the changing microbial threats associated with hostile vs. affine social conditions.
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