期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 7, 期 1, 页码 46-50出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.5b00318
关键词
Herpesvirus; HSV-1; varicella zoster; stem cells; Amaryllidaceae; alkaloid
资金
- NSERC
- Stanley Medical Research Institute
- NIMH [MH63480]
- CONACyT
The Amaryllidaceae alkaloid trans-dihydrolycoricidine 7 and three analogues 8-10 were produced via asymmetric chemical synthesis. Alkaloid 7 proved superior to acyclovir, the current standard for herpes simplex virus, type 1 (HSV-1) infection. Compound 7 potently inhibited lytic HSV-1 infection, significantly reduced HSV-1 reactivation, and more potently inhibited varicella zoster virus (VZV) lytic infection. A configurationally defined (3R)-secondary alcohol at C3 proved crucial for efficacious inhibition of lytic HSV-1 infection.
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