期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 38, 页码 16116-16121出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1109273108
关键词
genome dynamics; metabolic diversification; chromatin
资金
- UK Biotechnological Sciences Research Council
- Engineering and Physical Sciences Research Council
- Centre National de la Recherche Scientifique
- German Research Foundation
- Danish Research Agency
- BBSRC [BBS/E/J/000CA397] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000CA397, BBS/E/J/00000614] Funding Source: researchfish
- Division Of Physics
- Direct For Mathematical & Physical Scien [0943390] Funding Source: National Science Foundation
In bacteria, genes with related functions often are grouped together in operons and are cotranscribed as a single polycistronic mRNA. In eukaryotes, functionally related genes generally are scattered across the genome. Notable exceptions include gene clusters for catabolic pathways in yeast, synthesis of secondary metabolites in filamentous fungi, and the major histocompatibility complex in animals. Until quite recently it was thought that gene clusters in plants were restricted to tandem duplicates (for example, arrays of leucine-rich repeat disease-resistance genes). However, operon-like clusters of coregulated nonhomologous genes are an emerging theme in plant biology, where they may be involved in the synthesis of certain defense compounds. These clusters are unlikely to have arisen by horizontal gene transfer, and the mechanisms behind their formation are poorly understood. Previously in thale cress (Arabidopsis thaliana) we identified an operon-like gene cluster that is required for the synthesis and modification of the triterpene thalianol. Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary events that have led to cluster formation. We conclude that common mechanisms are likely to underlie the assembly and control of operon-like gene clusters in plants.
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