期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 24, 页码 9945-9950出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1100890108
关键词
molecular in vivo imaging; early detection; carcinoma in situ; genetically engineered mouse model; cathepsin
资金
- Deutsche Krebshilfe [108985]
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 824, Teilprojekt C9]
- Bundesministerium fur Bildung und Forschung [01 EZ 0802]
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor patient outcome often resulting from late diagnosis in advanced stages. To date methods to diagnose early-stage PDAC are limited and in vivo detection of pancreatic intraepithelial neoplasia (PanIN), a preinvasive precursor of PDAC, is impossible. Using a cathepsin-activatable near-infrared probe in combination with flexible confocal fluorescence lasermicroscopy (CFL) in a genetically defined mouse model of PDAC we were able to detect and grade murine PanIN lesions in real time in vivo. Our diagnostic approach is highly sensitive and specific and proved superior to clinically established fluorescein-enhanced imaging. Translation of this endoscopic technique into the clinic should tremendously improve detection of pancreatic neoplasia, thus reforming management of patients at risk for PDAC.
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