期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 6, 期 6, 页码 630-634出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml500409n
关键词
Alisertib; Aurora A kinase; MLN8054; MLN8237
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective, orally bioavailable inhibitors of Aurora A that have advanced into human clinical trials. Alisertib (10) is currently being evaluated in multiple Phase II and III clinical trials in hematological malignancies and solid tumors.
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