期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 52, 页码 20897-20901出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1110840108
关键词
conformation fluctuations; water phase transition; high-pressure cryocooling; X-ray crystallography
资金
- National Science Foundation (NSF)
- National Institutes of Health (NIH)/National Institute of General Medical Sciences under NSF [DMR-0936384]
- NIH through National Center for Research Resources [RR-01646]
Proteins are known to undergo a dynamical transition at around 200 K but the underlying mechanism, physical origin, and relationship to water are controversial. Here we report an observation of a protein dynamical transition as low as 110 K. This unexpected protein dynamical transition precisely correlated with the cryogenic phase transition of water from a high-density amorphous to a low-density amorphous state. The results suggest that the cryogenic protein dynamical transition might be directly related to the two liquid forms of water proposed at cryogenic temperatures.
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