期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 15, 页码 5986-5989出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1103118108
关键词
alanine ligation; desulfurization; leucine ligation; peptide; valine ligation
资金
- National Institute of Health [CA28824]
The power of chemical synthesis of large cysteine-free polypeptides has been significantly enhanced through the use of nonproteogenic constructs which bear strategically placed thiol groups, enabling native chemical ligation. Central to these much expanded capabilities is the specific, radical-induced, metal-free dethiolation, which can be accomplished in aqueous medium.
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