期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 23, 页码 10538-10542出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1000525107
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology
- Solution-Oriented Research for Science and Technology (Japan Science and Technology Agency)
- National Institute of Biomedical Innovation [ID05-24]
- Grants-in-Aid for Scientific Research [22659278] Funding Source: KAKEN
Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.
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