期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 6, 页码 2669-2674出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0910658107
关键词
cytokine; IL-1; inflammation; neural progenitor cell; depression
资金
- US Public Health Service [MH45481, 2 PO1 MH25642, R01 MH51399]
- Veterans Administration National Center
- Connecticut Mental Health Center
Proinflammatory cytokines, such as IL-1 beta, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-kappa B signaling in the actions of IL-1 beta and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by administration of an inhibitor of NF-kappa B. Further analysis reveals that stress activates NF-kappa B signaling and decreases proliferation of neural stem-like cells but not early neural progenitor cells in the adult hippocampus. We also find that depressive-like behaviors caused by exposure to chronic stress are mediated by NF-kappa B signaling. Together, these data identify NF-kappa B signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据