期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 1, 页码 67-72出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1007862108
关键词
cell therapy; tissue regeneration; controlled delivery; stimuli responsive; magnetomechanics
资金
- Materials Research Science and Engineering Center at Harvard University
- National Institutes of Health/National Institute of Dental and Craniofacial Research [R01 DE019917]
- BASF research initiative at Harvard University
- Defense Advanced Research Projects Agency [W911NF-10-0113]
- Pratt School of Engineering at Duke University
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.
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