期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 6, 页码 2652-2657出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0915059107
关键词
hippocampus; long-term potentiation; memory consolidation and reconsolidation; synaptic plasticity
资金
- CNPq
- Brazil and the Spanish Ministry of Science and Innovation [BFU2008-00899, BFU2008-03390]
- Junta de Andaluc a (Spain) [BIO-122, CVI-02487]
- Fundacion Conocimiento y Cultura of the Pablo de Olavide University of Spain
- European Community's [FP7/2007-2013, 201714]
- Programa de Pos-graduacao em Ciencias Medicas of the Federal University of Rio Grande do Sul
Long-term potentiation (LTP) phenomenon is widely accepted as a cellular model of memory consolidation. Object recognition (OR) is a particularly useful way of studying declarative memory in rodents because it makes use of their innate preference for novel over familiar objects. In this study, mice had electrodes implanted in the hippocampal Schaffer collaterals-pyramidal CA1 pathway and were trained for OR. Field EPSPs evoked at the CA3-CA1 synapse were recorded at the moment of training and at different times thereafter. LTP-like synaptic enhancement was found 6 h posttraining. A testing session was conducted 24 h after training, in the presence of one familiar and one novel object. Hippocampal synaptic facilitation was observed during exploration of familiar and novel objects. A short depotentiation period was observed early after the test and was followed by a later phase of synaptic efficacy enhancement. Here, we show that OR memory consolidation is accompanied by transient potentiation in the hippocampal CA3-CA1 synapses, while reconsolidation of this memory requires a short-lasting phase of depotentiation that could account for its well described vulnerability. The late synaptic enhancement phase, on the other hand, would be a consequence of memory restabilization.
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