期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 45, 页码 19396-19401出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1014515107
关键词
autoimmune disease; immunoglobulin G; inflammation
资金
- German Research Foundation [SFB 643, SPP 1468, DU548/2-1]
- Bavarian Genome Research Network
- Bavarian Academy of Sciences
- National Institutes of Health
Cellular Fc gamma receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fc gamma receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in Fc gamma RIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating Fc gamma Rs. To study the role of individual activating Fc gamma Rs for IgG subclass activity, we generated an Fc gamma RIV-deficient mouse and showed that a variety of IgG2a- and IgG2b- dependent effector functions are impaired in the absence of this activating Fc gamma receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.
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