期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 21, 页码 9742-9746出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0910668107
关键词
chromosome conformation capture; epigenetic; genetics
资金
- Doris Duke Clinical Scientist Development Award
- National Institutes of Health [R01 CA129435]
- Mayer Foundation
- H.L. Snyder Medical Foundation
- Dana-Farber/Harvard Cancer Center Prostate Cancer SPORE (National Cancer Institute) [5P50CA90381]
- Emerald Foundation, Inc.
- National Cancer Institute [R01 CA 109147, R01 CA 136924, CA089393]
- William L. Edwards Prostate Cancer Foundation
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据