期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 41, 页码 17763-17767出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1010461107
关键词
Alzheimer's disease; default mode network; positron emission tomography
资金
- National Institutes of Health [P50 AG05681, P50 NS006833, P20 MH077967, P01 AG003991, P30 NS048056, F30 NS057901]
Amyloid-beta (A beta) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism. Both the A beta plaque deposition and the changes in metabolism appear to be concentrated in the brain's default-mode network. In contrast to prior studies of brain metabolism which viewed brain metabolism from a unitary perspective that equated glucose utilization with oxygen consumption, we here report on regional glucose use apart from that entering oxidative phosphorylation (so-called aerobic glycolysis). Using PET, we found that the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with A beta deposition in individuals with DAT and cognitively normal participants with elevated A beta, suggesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology.
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