期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 8, 页码 3698-3703出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0914203107
关键词
breast cancer; biomarkers; invasion and migration; transcriptional profiling
资金
- National Cancer Institute [K08 CA100339, P50 CA89393]
- Richard & Susan Smith Family Foundation
- Howard Hughes Medical Institute
- Sidney Kimmel Foundation
- Breast Cancer Research Foundation
- Susan G. Komen Foundation [FAS0703860, KG0905151]
- U.S. Department of Defense [DAMD17-03-1-0408]
- Swiss National Science Foundation
- Emma Muschamp Foundation
Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding, however, of whether these correlative biomarkers link to a common biological network that regulates metastasis. We find that the c-MYC oncoprotein coordinately regulates the expression of 13 different poor-outcome cancer signatures. In addition, functional inactivation of MYC in human breast cancer cells specifically inhibits distant metastasis in vivo and invasive behavior in vitro of these cells. These results suggest that MYC oncogene activity (as marked by poor-prognosis signature expression) may be necessary for the translocation of poor-outcome human breast tumors to distant sites.
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