期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 48, 页码 20652-20654出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1003597107
关键词
allene; catalysis
资金
- National Institutes of Health (National Institute of General Medical Sciences) [R01-GM57034]
- University of Bologna
- Merck Research Laboratories
- Novartis
Because carbonyl groups are ubiquitous in organic chemistry, the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straightforward and versatile method for catalytic asymmetric carbon-carbon bond formation at the gamma-position of carbonyl compounds, specifically, phosphine-catalyzed additions of malonate esters to gamma-substituted allenoates and allenamides. Mechanistic studies have provided insight into the reaction pathway.
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