期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 31, 页码 13576-13581出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1003198107
关键词
X-ray imaging; differential phase contrast; grating interferometer; tomography
资金
- States Key Project for Fundamental Research [2009CB930804]
- National Natural Science Foundation of China [10490194, 10734070, 10504033, 10774144, 10979055]
- National Outstanding Youth Fund [10125523]
- Chinese Academy of Sciences [KJCX2-YW-N42]
- University of Geneva
- Vaud University Hospital Center
- University Hospital of Geneva
- Centre d'Imagerie Biomedicale of the University of Lausanne, Swiss Federal Institute of Technology, Lausanne
Phase sensitive X-ray imaging methods can provide substantially increased contrast over conventional absorption-based imaging and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems that have impaired the wider use of phase contrast in X-ray radiography and tomography. So far, to separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here we present an innovative, highly sensitive X-ray tomographic phase-contrast imaging approach based on grating interferometry, which extracts the phase-contrast signal without the need of phase stepping. Compared to the existing phase-stepping approach, the main advantages of this new method dubbed reverse projection are not only the significantly reduced delivered dose, without the degradation of the image quality, but also the much higher efficiency. The new technique sets the prerequisites for future fast and low-dose phase-contrast imaging methods, fundamental for imaging biological specimens and in vivo studies.
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