期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 108, 期 4, 页码 1451-1455出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1011293108
关键词
3-hydroxy-3-methyl-glutaryl-CoA; hemolytic anemia, elevated liver enzymes, and low platelet count; trophoblast
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
- Grants-in-Aid for Scientific Research [20062008, 22791528, 20670006] Funding Source: KAKEN
Preeclampsia is a relatively common pregnancy-related disorder. Both maternal and fetal lives will be endangered if it proceeds unabated. Recently, the placenta-derived anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG), have attracted attention in the progression of preeclampsia. Here, we established a unique experimental model to test the role of sFLT1 in preeclampsia using a lentiviral vector-mediated placenta-specific expression system. The model mice showed hypertension and proteinuria during pregnancy, and the symptoms regressed after parturition. Intrauterine growth restriction was also observed. We further showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor (PGF) and ameliorated the symptoms. We conclude that our experimental preeclamptic murine model phenocopies the human case, and the model identifies low-dose statins and PGF as candidates for preeclampsia treatment.
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