期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 34, 页码 15099-15104出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1010018107
关键词
BRD7389; pancreatic islets; Rsk kinase; transdifferentiation; beta cells
资金
- Juvenile Diabetes Research Foundation
- National Institute for General Medical Sciences [GM38627]
- National Institutes of Health [RL1-HG004671]
- Ernst Schering Research Foundation
- European Union [PIOF-GA-2008-221135]
- Harvard University
- National Institutes of Health-National Institute of Diabetes and Digestive and Kidney Diseases [DP2-DK083048]
High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a beta-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据