期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 52, 页码 22693-22698出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1012406108
关键词
estradiol-17 beta; conditional gene targeting; kiss1; arcuate nucleus; anteroventral periventricular nucleus
资金
- Deutsche Forschungsgemeinschaft [DFG BO1743/2]
- National Institutes of Health [K99 HD55446, P01 HD21921, T32 HD07068, P50 HD44405]
Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing hormone (GnRH). The timing and progression of puberty may depend upon temporal coordination of two opposing central mechanisms-a restraint of GnRH secretion before puberty onset, followed by enhanced stimulation of GnRH release to complete reproductive maturation during puberty. Neuronal estrogen receptor alpha (ER alpha) has been implicated in both controls; however, the underlying neural circuits are not well understood. Here we test whether these mechanisms are mediated by neurons that express kisspeptin, a neuropeptide that modulates GnRH neurosecretion. Strikingly, conditional ablation of ERa in kisspeptin neurons results in a dramatic advancement of puberty onset in female mice. Furthermore, subsequent pubertal maturation is arrested in these animals, as they fail to acquire normal ovulatory cyclicity. We show that the temporal coordination of juvenile restraint and subsequent pubertal activation is likely mediated by ER alpha in two separate kisspeptin neuronal populations in the hypothalamus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据