期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 8, 页码 3622-3627出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0914312107
关键词
genomics; Latimeria menadoensis; BAC clone
资金
- National Science Foundation [IOS-0321461, MCB-0719558, IOS-0321470]
- United States Department of Energy [DE-FG03-01ER63273, DE-FG03-01ER63272, DE-F602-01ER63274]
- Deutsche Forschungsgemeinschaft Bioinformatics Initiative [BIZ-6/1-2]
- Sixth Framework Programme of the European Union [043312, 043251]
The living coelacanth is a lobe-finned fish that represents an early evolutionary departure from the lineage that led to land vertebrates, and is of extreme interest scientifically. It has changed very little in appearance from fossilized coelacanths of the Cretaceous (150 to 65 million years ago), and is often referred to as a living fossil. An important general question is whether long-term stasis in morphological evolution is associated with stasis in genome evolution. To this end we have used targeted genome sequencing for acquiring 1,612,752 bp of high quality finished sequence encompassing the four HOX clusters of the Indonesian coelacanth Latimeria menadoensis. Detailed analyses were carried out on genomic structure, gene and repeat contents, conserved noncoding regions, and relative rates of sequence evolution in both coding and noncoding tracts. Our results demonstrate conclusively that the coelacanth HOX clusters are evolving comparatively slowly and that this taxon should serve as a viable outgroup for interpretation of the genomes of tetrapod species.
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