期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 8, 页码 3564-3569出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1000389107
关键词
bone morphogenic protein; neural induction; organizer; posterior development; retinoic acid
资金
- National Institute of Child Health and Human Development, National Institutes of Health
- Welcome Trust
- Biotechnology and Biological Sciences Research Council
- Biotechnology and Biological Sciences Research Council [BB/C51454X/1] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [22687016] Funding Source: KAKEN
In vertebrates, Evx homeodomain transcription factor-encoding genes are expressed in the posterior region during embryonic development, and overexpression experiments have revealed roles in tail development in fish and frogs. We analyzed the molecular mechanisms of posterior neural development and axis formation regulated by eve1. We show that eve1 is involved in establishing trunk and tail neural ectoderm by two independent mechanisms: First, eve1 posteriorizes neural ectoderm via induction of aldh1a2, which encodes an enzyme that synthesizes retinoic acid; second, eve1 is involved in neural induction in the posterior ectoderm by attenuating BMP expression. Further, eve1 can restore trunk neural tube formation in the organizer-deficient ichabod(-/-) mutant. We conclude that eve1 is crucial for the organization of the anteroposterior and dorso-ventral axis in the gastrula ectoderm and also has trunk-and tail-promoting activity.
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