期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 8, 页码 3406-3411出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0908531107
关键词
active biomaterials; layer-by-layer; nanostructured capsules; stem cells; tissue engineering
资金
- Agence Nationale de la Recherche [ANR06-BLAN-0197-01]
- Fondation Avenir
- Ligue contre le Cancer, Region Alsace
- Cancerople du Grand Est
- Australian Research Council
- FAST between France and Australia
- Faculte de Chirurgie Dentaire of Strasbourg
Interest in the development of new sources of transplantable materials for the treatment of injury or disease has led to the convergence of tissue engineering with stem cell technology. Bone and joint disorders are expected to benefit from this new technology because of the low self-regenerating capacity of bone matrix secreting cells. Herein, the differentiation of stem cells to bone cells using active multilayered capsules is presented. The capsules are composed of poly-L-glutamic acid and poly-L-lysine with active growth factors embedded into the multilayered film. The bone induction from these active capsules incubated with embryonic stem cells was demonstrated in vitro. Herein, we report the unique demonstration of a multilayered capsule-based delivery system for inducing bone formation in vivo. This strategy is an alternative approach for in vivo bone formation. Strategies using simple chemistry to control complex biological processes would be particularly powerful, as they make production of therapeutic materials simpler and more easily controlled.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据