期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 11, 期 2, 页码 674-682出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2015.2918
关键词
patchouli alcohol; acute lung injury; lipopolysaccharide; anti-inflammatory activity; antioxidative activity
资金
- National Natural Science Foundation of China [81303200, 81403169]
- Natural Science Foundation of Guangdong Province [S2013010016627]
- Administration of Traditional Chinese Medicine Project of Guangdong Province [20132142]
- Medical Scientific Research Foundation of Guangdong Province [A2013232]
- Ministry of Education of Guangdong Province [2012B090600007]
- Science and Technology Cooperation Project of Hong Kong, Macao, and Taiwan [2014DFH30010]
- Special Funds from Central Finance of China [276(2014)]
Patchouli alcohol (PA) is a tricyclic sesquiterpene isolated from Pogostemon cablin, which exerts anti-inflammatory, anti-influenza and cognitive-enhancing bioactivities. The present study aimed to investigate the protective effects of PA on acute lung injury (ALI) induced by intratracheal instillation of lipopolysaccharide (LPS) in mice. Dexamethasone was used as a positive drug for protection against LPS-induced ALI. The results of the present study demonstrated that pretreatment with PA significantly increased survival rate, attenuated histopathologic damage and lung edema, and decreased the protein content in the bronchoalveolar lavage fluid (BALF) of mice with ALI. Furthermore, PA significantly inhibited the expression levels of proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in the BALF, downregulated the levels of myeloperoxidase and malondialdehyde, and upregulated the activity levels of superoxide dismutase and glutathione peroxidase in lung tissue. These results indicated that PA may exert potent protective effects against LPS-induced ALI in mice, the mechanisms of which are possibly associated with the anti-inflammatory and antioxidative activities of PA.
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